Global Journal of Biology, Agriculture & Health Sciences

Abstract

The Role of some Medicinal Plants in Reducing Sperm DNA Damage of Male Mice

Nasir, A .Ibrahim, Omer Arabi, Motamn, A. Kahil

The aim of this study was to investigate the role of some medicinal plants in reducing sperm DNA damage of male mice. The plants (ginger, Coriandrum sativum ,Hibiscus sabdariffa and Garcinia kola) were subjected to preliminary phytochemical screening to identify the chemical constituents. Adult mice (n=50) were included in the present study. Thereafter, the mice were randomly divided into control (n=10) and experimental (n=40) groups. The control group just received 8ml distilled water daily. However, the experimental 100gm/Kg/BW of ginger, Coriandrum sativum ,Hibiscus sabdariffa and Garcinia kola for 21 consequence days in water. The present study was showed on the preliminary phytochemical analysis result of the aqueous ginger, Coriandrum sativum, Garcinia kola and Hibiscus sabdariffa found that the presence of varying amount of alkaloids, saponins, tannins, cardiac glycosides, cardenoledes, flavonoids steroidal ring, and phlobatanins in the concentrations. Sugar, phlobatanins and tannins were absent in ginger. While alkaloid, phlobatanins and saponins were absent in Coriandrum sativum and steroidal ring in Hibiscus sabdariffa.While on DNA damage the study found the ginger effect there was 94% of sperm with normal morphology and 3% immature and DNA Damage 3% when in Coriandrum sativum there was 91% of sperm with normal morphology and 7.5% immature and DNA Damage 2.5% and the effect of Garcinia kola and Hibiscus sabdariffa there were 89% ,79% of sperm with normal morphology , 5.5%,14% immature and DNA damage 5.5%,7% respectively compared with control group 85% of sperm with normal morphology and 7%,8% immature and DNA Damage.

Published Date: 2014-10-08;