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Abstract
The Role of COX-2 in Knee Osteoarthritis: A Comprehensive Analysis of Cytokines, Inflammation and Signaling Pathways
You Zhou* and Chaoxin Liang
Knee Osteoarthritis (KOA) of the knee is a prevalent joint disorder closely associated with multiple factors, among which Cyclooxygenase-2 (COX-2) plays an important role in inflammatory responses and cytokine release. This review aims to elucidate the role of COX-2 in the pathogenesis of knee osteoarthritis, analyze its interplay with key cytokines and examine the signaling pathways involved in this process. By employing immunehistochemical techniques, we intend to gain a deeper understanding of the expression patterns of COX-2 and its functions within the inflammatory microenvironment, thereby providing new insights for the treatment of knee osteoarthritis.
Published Date: 2024-11-22; Received Date: 2024-10-23