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Abstract
The Protection Potential of an Alum-Adjuvanted F1 Protein in Dry Powder against Plague in Mice
Wang Wang, Yiran Liu, Xiangna Zhao, Zongmin Du, Yafang Tan, Yujing Bi, Yanping Han, Ruifu Yang and Xiaoyi Wang
Aluminum hydroxide is the only adjuvant for use in human vaccines. The commercial alum-adjuvanted vaccines are formulated as liquid without exception. We prepared an alum-adjuvanted dry powder vaccine and demonstrated that it provided good protection for plague. The preparation strategy is simple and effective and can be carried out in a large scale. The dry powder vaccine can be quickly reconstituted using sterile water for injection. The dry powder vaccines have potential advantages over liquid vaccines, including good stability and extended shelf life.