Journal of Clinical & Experimental Pharmacology

Abstract

The Onset of Action of Aqueous Extracts of Ceiba pentandra (Malvaceae) and Pseudocedrela kotschyi (Meliaceae) Plants with Potential Antipyretic Activity on Young Rats and their Interactions with Antimalaria Drugs (Artemisinin-based Combination)

Djadji ATL, Effo KE, Any-Grah-Aka S, Kouakou SL, Irie-N’Guessan G and Kouakou-Siransy G

Background: Several classical antipyretics are used to treat fever. But their harmful sides effects have led to the research of the others alternative based on medicine herbals. Rarely, studies are focused on the onset of action and assess the effects of Drugs Herbal interaction in vivo using experimental models. The main objective of this work is to assess potential antipyretic activities of two African plants (Ceiba pentandra and Pseudocedrela kotschyi concerning the onset of action and evaluate the effects of their association to the combination based on artemisinin (CTA).
Methods: Turpentine 2 ml/kg, yeast brewers 20%, boiled milk 1 ml/kg were used to induce fever in young rats. The crudes of the extract of Ceiba pentandra 200 mg/kg; 400 mg/kg and Pseudocedrela kotschyi 100 and 150 mg/kg were administered orally and the temperatures (°C) were taken each 10 minutes. The Drugs-Herbal medicine interactions were also assessed (Extracts of our plants plus CTA). GraphPad Prism software version 7 was used to analyse the data. The difference was considered significant when P<0.05.
Results: Aqueous extract of the Ceiba pentandra and Pseudocedrela kotschyi quickly reduce the fever by reducing the onset time of action (10-30 minutes). P-value<0.001 but our study has shown pharmacodynamics interaction between CTA and Pseudocedrela. There may have some interaction between CTA and the natural compounds contained in these medicine plants that reduce their efficacy.
Conclusion: This present study showed the onset action of our two plants is between 10-30 minutes. Their association with CTA reduce the efficacy of extracts aqueous of leaves of Pseudocedrela kotschyi 150 mg/kg but no Ceiba pendantra 400 mg. They may be used as an alternative to classical drugs as antipyretics especially in children. But others studies may be done to assess the pharmacokinetic pharmacodynamics interactions with association based on artemisinin.