Journal of Vascular Medicine & Surgery

Abstract

The Effect of Prostaglandin Therapy on Ankle Brachial Index in Non- Reconstructable Symptomatic Peripheral Artery Disease Patients- Retrospective Analysis

Sandeep Mahapatra, Pinjala Ramakrishna, Puneeth Joopalli and Mujtaba hussain Naqvi Syed

Background: Prostaglandin E1 has been reported to benefit patients with significant peripheral vascular disease
and limb threatening ischemia. The present retrospective study attempts to assess the effect of Prostaglandin E1 on
ankle brachial index in non reconstructable symptomatic peripheral artery disease patients.
Objectives: To study the effect of Prostaglandin E1 on ankle brachial index in non reconstructable symptomatic
peripheral artery disease patients.
Methods: Case records of 40 patients who had completed at least six cycles of injection were obtained from
medical records of vascular surgery. The demographic data and the ankle brachial index of these patients were
recorded at baseline and at the end of six cycles of the drug.
Results: The average ABI of both the limbs changed significantly from baseline to the end of study after six
cycles of Prostaglandin E1 injection (p<0.05). There was significant increase in Ankle brachial index for the
symptomatic limb from baseline whereas the contra lateral limb did not show a significant change. There was a
significant increase in Ankle brachial index of both limbs as well as the average Ankle brachial index in the patients
without any co-morbidities conditions than those with the presence of co-morbidities.
Conclusion: Prostaglandin E1 therapy increases the ankle brachial index in symptomatic limb of patients with
non reconstructable symptomatic peripheral artery disease patients.