Pharmaceutica Analytica Acta

Abstract

The Effect of Different Contraceptive Drugs on the Lipid Profile of Brazilian Women

Bianca Stocco, elen F. Fumagalli, Silvio Antônio Franceschini, Cleni Mara Marzocchi Machado and Maria Regina Torqueti Toloi

Purpose: Evaluating the concentration of the lipoproteins HDL, LDL, VLDL, triglycerides and total cholesterol in the serum of women who use oral combined contraceptives containing anti-androgenic progestogen in comparison to control group. Method: Cross-sectional study developed with 47 women (18 to 30 years), distributed into two groups of patients who used oral contraceptive drugs containing 20 or 30 ?g de Ethinylestradiol (EE) combined to Drospirenone (DRSP), compared to a control group. The serum levels of lipids (Total cholesterol, Triglycerides and HDL) were quantified through Trinder?s method. The levels of LDL and VLDL were obtained through mathematical formulas. Results: In the users of DRSP/30EE there was an increase in the levels of total cholesterol, triglycerides, HDL and VLDL in relation to control group. In the users of DRSP/20EE, there was an increase in the levels of total cholesterol and HDL. Conclusion: The anti-androgenic progestogen drospirenone was not effective to counterbalance the beneficial effect of the estrogen on the levels of the lipoprotein HDL.