Biochemistry & Analytical Biochemistry

Abstract

Synthesis and Cytotoxicity of Dinuclear Silver(I)-N-Heterocyclic Carbene Complexes

Muhammad Adnan Iqbal, Rosenani A Haque, Mohamed B Khadeer Ahamed and Abdul Majid AMS

Synthesis of two new para-xylyl linked bis-benzimidazolium salts (III-IV) and respective dinuclear Ag(I)-N-heterocyclic carbene complexes (V-VI) has been described. The compounds were tested against human colorectal cancer cells (HCT 116) which showed a dose-dependent cytotoxic activity. The IC50 values were found in the range 0.03–65.9 μM. 5-Fluorouracil was used as standard drug (IC50=5.9 μM).