Indexed In
- Open J Gate
- Genamics JournalSeek
- Academic Keys
- JournalTOCs
- The Global Impact Factor (GIF)
- China National Knowledge Infrastructure (CNKI)
- Ulrich's Periodicals Directory
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- Google Scholar
Useful Links
Share This Page
Journal Flyer
Open Access Journals
- Agri and Aquaculture
- Biochemistry
- Bioinformatics & Systems Biology
- Business & Management
- Chemistry
- Clinical Sciences
- Engineering
- Food & Nutrition
- General Science
- Genetics & Molecular Biology
- Immunology & Microbiology
- Medical Sciences
- Neuroscience & Psychology
- Nursing & Health Care
- Pharmaceutical Sciences
Abstract
Stability-Indicating Spectrophotometric Determination of Aceclofenac Using Multivariate Calibration
Jenny Jeehan Nasr, Ahmed Ashour, Manal Eid, Amina Elbrashy and Fathalla Belal
Two simple, rapid and inexpensive chemometric spectrophtometric methods were established for the stabilityindicating determination of aceclofenac in presence of its degradation product; diclofenac. The applied chemometric techniques are multivariate methods including partial least squares (PLS) and concentration residual augmented classical least squares (CRACLS).The UV absorption spectra of the standard solutions of the training and validation sets in phosphate buffer of pH 6 were recorded in the range of 220-330 nm at 1.0 nm intervals. The developed methods were validated and successfully applied to the analysis of aceclofenac in pharmaceutical dosage forms and in bulk powder. The assay results obtained using the chemometric methods were statistically compared to those of a reference HPLC (high performance liquid chromatographic) method and a good agreement was observed.