Journal of Vaccines & Vaccination

Abstract

Post-Vaccine SARS-CoV-2 Reinfection and Associated Factors among Health Care Providers with Pre-Vaccination Infection History in Addis Ababa Public Hospitals, Addis Ababa, 2022

Enyew Belay*

Background of the study: The protection against Corona virus diseases 2019 variants by preexisting antibodies elicited due to the current vaccination or natural infection is a global concern. Even though studies are not found as per the investigators’ scope in Ethiopia case reports show that’s a significant number of health professionals are reported to get re-infected after vaccination. Nevertheless, there are more studies which revealed the symptomatic SARS-CoV-2 re-infection rate and associated factors elsewhere in Ethiopia, and in particular amongst healthcare providers actively engaged in Addis Ababa public health facilities.

Objective: This study has aimed at assessing the magnitude of post vaccine reinfection of SARS-CoV-2 and associated factors among health care providers with history of pre-vaccination infection history in Addis Ababa public hospitals, Addis Ababa, 2022 G.C

Methods: Facility based cross-sectional study was conducted from July 11 to July 30, 2022. A total of 422 health professionals were included. First simple random sampling method was employed to select 40% of the total hospitals. Then the total sample size was equally allocated to each selected hospital then after each individual was selected purposely. The data was collected using structured self-administered questionnaire. The analysis was done by using SPSS version 26.0 and for data entry EPi info version 7.1 was used. Both bivariable and multivariable logistic regression analyses were used to determine p value.

Results: The finding of this study revel that the magnitude of SARS-CoV-2 reinfection and associated factors among health care providers with history of pre-vaccination infection history is 60 (14.4%) (95% CI 10.8-17.9). In multivariable analysis, health care Professionals who took IP training on COVID-19 (AOR=7.177: CI=4.761-9.698), chronic respiratory diseases (AOR=3.029: CI=2.406-9.133), health professionals who took third dose of SARS-CoV-2 vaccine (AOR=1.75: CI=1.14-2.68) and being a midwife had statically significant.

Conclusion and recommendation: This study showed the prevalence of SARS-CoV-2 reinfection among vaccinated health care providers with pre-vaccination infection history was high, IP training on COVID-19, educational status, profession, type of vaccine up taken in 1st dose, chronic respiratory diseases, number of vaccination status were significantly associated with SARS-CoV-2 reinfection after vaccination. Giving infection prevention training, encouraging taking the vaccine as protocol and using proper personal protective equipment is recommended.

Published Date: 2023-03-01; Received Date: 2022-10-07