Journal of Aging Science

Abstract

Oxidative Stress and Diseases: Current Topics and Perspective with Clinical Application in Japan

Eiichiro Ichiishi, Takaaki Ohtake, Kiichi Satoh and Yutaka Kohgo

Evaluation of oxidative stress and diseases have markedly progressed and developed in basic science, and various trials of prevention and treatment have recently been performed at clinical levels, making remarkable progress in medical practical field. This report will introduce recent topics in Japan and other countries and review Japanese reports of oxidative stress pathways and development of healthy products, current topics and problems with molecular hydrogen, oxidative stress markers attracting attention at clinical practices, recent knowledge on oxidative stress and the immune system, and new development in regenerative medical treatment. A problem with the above development in clinical fields and application of oxidative stress is that health foods and beverages allegedly effective for reducing oxidative stress are already on the market but there are more than a few of them have a poor scientific evidence and their effects are questionable. Unquestionable bases and evidence of ‘oxidative stress and diseases’ have already accumulated in basic medicine. I hope these will be actively applied in clinical fields, accumulate evidence by performing systematic clinical studies and trials, and actually facilitate health promotion, disease prevention, and treatment effects in humans, making great contributions at actual medical practical care.