Biology and Medicine

Abstract

Maintenance of Endothelial Cell Function in Liquid Based Antithrombotic Surface Coating

Hunghao Chu, Jiaqi Yao, Tuo Zhang, Mighten C Yip, Mousumi Dhara, James K Min, Simon Dunham and Bobak Mosadegh

Preventing occurrence of thrombosis and biofouling is essential for safety and efficacy of an intravascular device. The slippery liquid-infused porous surface (SLIPS) technology has promise to achieve this goal by forming a liquidrepellent layer on the surface of blood contacting materials. As adhesion of biomolecules is greatly inhibited, the SLIPS-treated surface reduces thrombosing and biofouling. This study demonstrates that in static conditions, cells can adhere to SLIPS-treated surfaces without significant decreases in attachment or migration, as compared to untreated polymer surfaces. Furthermore, next generation RNA sequencing reveals that the SLIPS treatment does not change gene expression in endothelial cells (ECs). Taken together, our findings suggest that SLIPS treatment to be a biocompatible strategy that could potentially protect a variety of medical devices without compromising the process of endothelialization.