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Abstract
Importance of High Grade Transformation and Translocations in Salivary Gland Neoplasms
Henrik Hellquist
The concept of high grade transformation in human neoplasms was introduced in 1971 by the report demonstrating that 33 of 370 cases of well differentiated (low-grade) chondrosarcomas contained areas of a high-grade sarcoma. Currently at least 23 different types of primary salivary carcinomas are recognized, some of low and others of high grade malignancy.