Journal of Blood Disorders & Transfusion

Abstract

Immune Thrombocytopenia in Chronic Lymphocytic Leukemia

Amelia Maria Gaman and Mihnea-Alexandru Gaman

Introduction: Chronic lymphocytic leukemia (CLL) is a malignant proliferation of mature, differentiated B-lymphocytes associated in 1-5 % of cases with immune thrombocytopenia (ITP). The effect of ITP on the clinical outcome and survival of patients with CLL is controversial.

Materials and methods: The aim of the study was to evaluate the level of oxidative stress in patients with CLL and ITP and how this complication influences the patient’s survival. We studied 84 patients with CLL hospitalized in the Clinic of Hematology from Craiova (Romania) between 2007 and 2012 .The global oxidative status at diagnosis of CLL and in the presence of ITP by FORT (Free Oxygen Radicals Testing) and FORD (Free Oxygen Radical Defence) tests and the median overall survival in patients with CLL - stage C immune disease compared to stage C-infiltrative disease were evaluated.

Results and discussion: All patients with CLL had low FORD values and high FORT values and there were no significant differences of oxidative stress between patients with CLL and ITP compared to patients with CLL without ITP. Oxidative stress did not play a role in the appearance of ITP in CLL. The patients with CLL-stage C immune disease had a longer survival than the patients with CLL-stage C infiltrative disease.

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