Global Journal of Biology, Agriculture & Health Sciences

Abstract

HISTOLOGICAL EFFECTS OF MORINGA EXTRACT ON CARBON TETRACHLORIDE INDUCED HEPATOXICITY IN ADULT WISTAR RATS.

Ezejindu D.N., Chinweife K. C., & Ihentuge C.J

This study was carried out to determine the effect of moringa extract on carbon tetrachloride induced hepatotoxicity in adult Wister rats. Twenty rats weighing between 150 – 220g were used. The rats were divided into four groups A, B, C, D of five animals each. Group A served as the control group and received 0.5ml of distilled water. The experimental groups received different doses of drugs as follows; Group received 0.8ml of extract, Group C received 0.4ml of carbon tetrachloride while Group D received 0.4ml and 0.8ml of moringa extract. The administration lasted for twenty days between the hours of 12- 3.30pm using intubation method. Twenty four hours after the last administration, the animals were anestathized under chloroform vapour and diseected. Liver tissues were removed, weighed and fixed in zenker’s fluid for histological studies. The relative liver weights for group C were significantly higher than the control. The relative liver weight of group B and C increased significantly relative to the control group. The histological results reveal distortion of liver cells in group C and normal cell architecture in group Band C. the extract has a hepatprotective effects on carbon tetrachloride induced hepatotoxity.

Published Date: 2013-05-08;