Journal of Clinical & Experimental Pharmacology

Abstract

Hemodynamic Effect of 2% Lidocaine with a 1:100,000 Adrenaline in Patients with Cardiovascular Diseases Undergoing Single Tooth Extraction

Shehab Ahmed Hamad*, Ranj Nadhim Salai and Avinash Nandan

Objective: To assess the effect of vasoconstrictor in dental local anaesthetic on hemodynamic parameters in patients with cardiovascular disease following tooth extraction.

Methods: This prospective study was conducted at Al-Manara college for medical sciences, Amarah, Iraq. The sample of the study included 50 patients with cardiovascular disease who were presented for extraction of a single mandibular molar under local anaesthesia. The local anaesthesia was achieved with inferior alveolar nerve block using single cartridge of 2% lidocaine with 1:100,000 adrenaline. Systolic and diastolic blood pressure, heart rate, and oxygen saturation were measured before injection, immediately after injection, and after 5 and 15 minutes of injection.

Results: Although the systolic blood pressure and heart rate were elevated, the diastolic blood pressure was decreased and no change was seen in the oxygen saturation.

Conclusion: The local anaesthetic injection of lidocaine with adrenaline, along with the surgical procedure of tooth extraction, produces significant increase in the systolic blood pressure and heart rate in the patients with cardiovascular diseases.

Published Date: 2024-03-11; Received Date: 2023-06-14