Journal of Ocular Infection and Inflammation

Abstract

Eye a Window to Granulomatosis with Polyangiitis: A Review

Jasreen Kaur Sandhu*

Granulomatosis with Polyangiitis (GPA), a type of vasculitis, is characterized by necrotizing inflammation of smallmedium blood vessels and is associated with Anti-Neutrophil Cytoplasmic Antibodies (ANCA). While GPA commonly affects the upper respiratory tract, lungs, and kidneys, ocular manifestations can also occur, ranging from 28% to 58% of cases. Ocular involvement in GPA can present as scleritis, keratitis, conjunctivitis, uveitis, or orbital involvement. Prompt diagnosis is crucial as ocular manifestations can lead to irreversible damage and vision loss. This review article discusses the ophthalmic manifestations of GPA, including their clinical features, diagnosis, and treatment options. Additionally, it explores the etiology of GPA, including genetic and epigenetic factors, environmental risk factors, and medications associated with the disease. The article aims to provide a comprehensive understanding of ocular manifestations in GPA and identify gaps in the existing literature for further research.

Methodology: PubMed was used and source of information, and articles pertaining to (“GPA”AND”Ophthalmological manifestations”), (“GPA”AND”Ophthalmic manifestations”), (“GPA”AND”Eye”) were found. Initially only latest publications were considered (up to 5 years old), but if all information was not available then previous publications were also taken.

Published Date: 2025-01-16; Received Date: 2023-07-08