Pharmaceutica Analytica Acta

Abstract

Extemporaneous Compounding of Furosemide Oral Liquid Formulations: A Systemic Review

Imraan Joosub*, Mohammed Al-Anezi, Zohair Emara and Eman Youssif

Small-scale compounding of oral liquid dosage forms lacks long-term safety and efficacy data of commercially available medicines. Medication shortages of furosemide syrup continue to burden healthcare treatment. Extemporaneous compounding of commercially available registered drugs is prohibited, except under exceptional circumstances. Compounding an alcohol-free furosemide oral liquid may be safe for pediatric patients. This study aims to alleviate a nationwide shortage of furosemide syrup via a literature review of extemporaneous compounding resources. Investigators performed a literature review and found that 8 of the 13 stability studies of furosemide oral liquids were alcohol-free with at least a 30-day shelf life, and may be suitably compounded for pediatric patients. In the absence of a commercially available furosemide syrup, this review found safe alternatives to extemporaneously compound furosemide oral liquid dosage forms.

Published Date: 2023-08-25; Received Date: 2023-07-24