Biology and Medicine

Abstract

Evaluation of Pharmacological and Toxicological Studies of Ayurvedic Medicine Siddha Makardhwaja on Biological System of Male Sprague-Dawley Rats

Md. Mamun Sikder, Nilay Saha, Umma Hafsa Asha, Md. Nuruzzaman Neon, Khadija Akter, Manoth Kumer Biswas, Md. Rakib Hasan, M. S. K. Choudhuri

In this study, the pharmacological and toxicological effects along with possible side effects of the classical ayurvedic formulation Siddha Makardhwaja (SMD) which is used as a traditional medicine in the treatment in the rural population were evaluated. During this study, various experiments on organ body weight ratio and tissue hydration indices were performed to evaluate its effi cacy and toxicity. SMD was administered chronically to the male Sprague-Dawley rats at a dose of 40 mg/kg to determine its toxicological characteristics. After 28 days of chronic administration of the prepared SMD, the following toxicological changes were noted: a statistically very highly signifi cant (p = 50.001) decrease in the absolute weight of the male rat liver [26.55% decrease]; a statistically highly signifi cant (p50. 002) decrease in the relative percent weight of the male rat liver [19.45% decrease]; a statistically highly signifi cant (p = 50.006) increase in the relative percent weight of the male rat kidney [17.73% increase]; and a statistically signifi - cant (p = 50.041) decrease in the organ water content of the male rat kidney [4.50% decrease]. As SMD decreases and increases abnormally the weight of several organs in the body of treated rats, it should not be administered chronically at a higher dose.