Journal of Liver

Abstract

Effects of Ginseng Polysaccharides on Hepatocellular Energy Metabolism in Hepatic Ischemia Reperfusion Injury in Rabbits

Haie Chen, Yingchun Ma, Lei Ying, Dan Chen, Yakun Liu, Shan Zhao, Guanlong Li and Wantie Wang

Objective: To investigate the effects of ginseng polysaccharides on hepatocellular energy metabolism in Hepatic Ischemia reperfusion injury of rabbits.

Methods: 30 rabbits were randomly divided into 3 groups: Control Group (C), Ischemia-Reperfusion Injury Group (IR) and Ginseng Polysaccharides Group (GP). We investigated Alanine Aminotransferase (ALT) in plasma, Adenosine Triphosphate (ATP), Adenosine Diphosphate (ADP), Adenosine Monphosphate (AMP), Total Adenylic Acid Number (TAN), and Energy Charge (EC) in liver and morphological changes of hepatic cells.

Results: In group IR, the content of ATP and EC in hepatic tissue were obviously less than those of group C (P<0.01). The content of ADP and AMP was more abundant than those of group C (P<0.01). In both groups there was little or no significant content of TAN (P>0.05), and was obviously morphological abnormality in hepatic tissue. In group GP, the content of ATP was more abundant (P<0.01) and the content of ADP and AMP were evidently less than those of group IR (P<0.01 or P<0.05); The content of ATP was even less than that of group C (P<0.05); the content of TAN had significantly statistical difference between group GP and group C (P>0.05), and morphological abnormality in hepatic tissue was obviously reduced.

Conclusion: Ginseng polysaccharides could attenuate Hepatic Ischemia Reperfusion Injury (HIRI) by improving hepatocellular energy metabolism.