Biology and Medicine

Abstract

Effect of Sodium Selenite on Testicular Damage Induced by Cisplatin in Adult Male Rats

Dilek Burukoglu Donmez and Seren Bozdoğan

Cisplatin is an established chemotherapeutic substance commonly used in the treatment of cancer. Several reports have been published on its antineoplastic activity and toxicity however, no details are available on its noxious effects on the genital system organs such as testes. Another interesting element Selenium and its derivatives including Sodium selenite are reported to form the active center of glutation peroxidase which has antioxidant properties involved in antioxidant balance of the cells and in lipid peroxidation. This study was aimed to explore the effects of selenium against the damage caused in testes of rats by Cisplatin treatment. Sprague-Dawley rats 28 in number were randomly allotted to different standard and treatment groups. All the animals in different experimental groups were maintained under controlled standard conditions. The results clearly demonstrated that Cisplatin treatment decreased the weight of testes as well as the body weight of rats. Furthermore, it damaged seminiferous tubules and cells in testes of animals in the treatment groups, and halted the process of spermatogenesis. Selenium treatment reduced the damage caused by Cisplatin treatment. The results of the present study were substantiated by detailed histopathological investigations