Biology and Medicine

Abstract

Effect of Guibourtia tessmannii extracts on blood lipids and oxidative stress markers in triton WR 1339 and high fat diet induced hyperlipidemic rats

CF Nyangono Beyegue, RM Chakokam Ngangoum, D Kuate, JL Ngondi, J Enyong Oben

The present study evaluated the effect of aqueous and hydroethanolic extracts of Guibourtia tessmannii on blood lipids and oxidative stress markers in both triton (WR-1339) and high fat diet induced hyperlipidemic rat models. Results revealed that treatment of tritonized hyperlipidemic rats with G.tessmannii extracts at dose of 200 mg/kg BW resulted in a significant reduction in total cholesterol (TC), triglyceride (TG) and lipid peroxide (MDA) levels (p<0.05). In high fat diet induced hyperlipidemic rats model, feeding with the atherogenic diet for 30 days significantly increased the plasma levels of TG, TC, LDL-C, LDL/HDL, TC/HDL ratios, as well as a significant elevation of lipid peroxide levels in both plasma and liver. Co-administration of the G.tessmannii extracts at dose of 200 mg/kg BW along with a high fat diet reversed these changes. These beneficial effects could be attributed to the antioxidant activities of bioactive ingredients in both extracts.