Biology and Medicine

Abstract

Determinants of Insulin Resistance in Viral Hepatitis C and Hepatic Steatosis Interaction

Mpiana Mutombo Baby, Nganga Nkanga Mireille, Tshimpi Wola Yaba Antoine, Kuyangisa Boloko Bienvenu, Bikaula Ngwidiwo Jacques, Salaboni Munzengi Vandersal-Alain, Matondo Grace Patricia, Bakemo Bombile Eddy, Kisoka Lusunsi Christian, Longo-Mbenza Benjamin* and Mawalala Malengele Heritier

Background: The Hepatitis C virus, through its proteins, blocks the insulin signaling pathway, thus causing insulin resistance. He also interferes in lipid metabolism leading to hepatic steatosis. The objective of this study was to determine the effects of the interaction of viral Hepatitis C and hepatic steatosis on insulin resistance in non- diabetic patients in Kinshasa.

Methods: It was a cross-sectional analysis carried out between 2021 and 2022 in non-diabetic patients suffering from Hepatitis C at Biamba Marie Mutombo Hospital (HBMM), Masina/Kinshasa.

Results: Of the 120 patients, 64 were women (53%) and 56 were men (47%), the average age was 71 ± 21 years, the majority of patients, i.e. 67.5% (n=81), were characterized by advancing age, compared to a third of patients, i.e. 32.5% (n=39) without advancing age. There was an epidemic magnitude of insulin resistance estimated at 75% among 120 patients with viral Hepatitis C. The proportions of insulin resistance varied statistically unequally in the different interaction groups between Hepatitis C infection and hepatic steatosis (P<0.000 1). Advancing age ≥ 60 years and very urbanized/polluted residence were the independent determinants of insulinoreresistance. SBP and BMI significantly discriminated against viral Hepatitis C.

Conclusion: This study confirmed that Hepatitis C interacts strongly with fatty liver handled with insulinoresistance in people prearranged.

Published Date: 2024-01-29; Received Date: 2023-12-28