Journal of Stem Cell Research & Therapy

Abstract

Cystic Fibrosis

Nikita Tiwari*

Cystic fibrosis also known as CF is a life threatening, hereditary disease which is non- curable autosomal recessive disorder and is chronic in nature. Almost, 100,000 of the world population is suffering from this disease at the current time and it is most commonly found in Caucasians. CF is caused due to the mutations caused in CETR genes that is cystic fibrosis trans membrane regulator gene.

In this disease the mucus becomes thicky and accumulates in organs associated with the respiratory system and GIT such as lungs, sinuses, pancreas, intestine, hepatobiliary tree, vas derens etc. causing dehydration and abnormality of chloride channels in mucus and sweat secreting cells, therefore causing problems in gastrointestinal tract and respiratory tract. It increases the risk of malignant tumors and cancer in gastrointestinal and pancreato-biliary tract and recurrent or acute pancreatitis, thus affecting the gut. Respiratory system is highly affected in this disease and the risks of bronchitis, asthma, pneumonia and several other air borne allergies is very high.

Published Date: 2023-02-28; Received Date: 2020-12-07