Journal of Vaccines & Vaccination

Abstract

Comparison Prior and Post Vaccination of Inactivated Recombinant Vaccine Against Mannheimiosis in Boer Goats Farm in Sabah

Sabri MY, Shahrom-Salisi M and Emikpe BO

The study was conducted to evaluate the efficacy of inactivated recombinant vaccine of Mannheimia haemolytica (MH) against naturally occurring mannheimiosis in a breeding Boer goat farm in Sabah, Malaysia. From the inception of Rural Development Corporation (RDC) farm in year 2005, the farm suffered a high incidence of mannheimiosis, one of the major caprine respiratory diseases in Malaysia. In order to reduce the incidence of the disease, the efficacy of the laboratory tested inactivated recombinant vaccine for mannheimiosis (RVM) was carried out on the farm goats. Goats more than 6-months-old were given the vaccine intranasally, followed by a booster dose on day 14, and subsequently a second booster dose was administered at 6 month interval (for two years). The data of goats that died of mannheimiosis were collected based on gross pathology and subsequent bacterial isolation to confirm the diagnosis. The effect of vaccination was evaluated by review of mortality pattern attributable to mannheimiosis during the three year study that spanned between 2006 and 2008. There was significant reduction of incidence and
mortality attributable to mannheimiosis in RDC farm with a resultant drop in mortality rate from 10-22 death per month to 3-2 per month after vaccination also 3.71% in 2006 prior to the introduction of the vaccination regime to 0.08% after the introduction in 2008. This is clearly showed that the RVM is suitable to be use on the farm goats.