Pharmaceutica Analytica Acta

Abstract

Comparative Study of Data Generated by Structural Annotation of the Genome for Identifying the Unique Parameter Responsible For Pathogenic Property of Helicobacter Pylori

Megha Vaidya and Hetal Kumar Panchal

Helicobacter pylori are the most common bacterial infection worldwide. They are generally acquired during childhood and the infection can persist in gastric ecosystem throughout the life span of the host, if untreated. There are similarities and the variations in the size of genomes of several strains. The disease causing factor Cag Pathogenic Island is present in almost all the strains but yet the different strains cause different diseases. In present studies, detailed comparative studies of each genomes is carried out to check possibility of prediction of the type of disease it would cause and suggest some target for treatment on the bases of structural annotation. It is found that comparative studies of structural features of genomes give important outcomes but, cannot give detailed idea about the type of disease the strains would cause. Functional analysis of genome or study of gene order and rearrangement of genome may solve the mystery of disease specific genes and give some better target for treatment.