Biology and Medicine

Abstract

Comparative Study of Anti-Hyperglycemic and Anti-Hyperlipidemic Effects of Honey, Coccinia cordifolia and Hilsha Fish Oil in Streptozotocin Induced Diabetic Rats

Rahman MS, Asaduzzaman M, Munira S, Begum MM, Rahman MM, Hasan M, Khatun A, Maniruzzaman M, Islam M, Khan MHK, Rahman M, Karim MR and Mohammad Amirul Islam

This study was aimed to evaluate the efficacy of Honey, Coccinia cordifolia (Locally known as Telakucha) leaves and Hilsha fish oil as hypoglycemic and hypolipedemic agents in diabetic condition. The leaves were initially under shade, grinded to powder, extracted with ethanol and filtered through Whatmann filter paper. The filtrate was concentrated by rotatory evaporator and stored at 4°C. The experimental rats were divided into six groups (n=6). Diabetes mellitus (DM) was induced by single intraperitoneal injection (65 mg/kg BW) of freshly prepared streptozotocin hydrate solution in 0.9% saline solution. Hyperlipidemic was induced by mixture of cholesterol (1.5 %) and cholic acid (0.5%) with diet of rats. At the end of the treatment, the blood glucose level and lipid profile was measured by using commercial kits. It was observed that honey, plant leaves extract and Hilsha fish oil (HFO) have potential hypoglycemic effect as it significantly (p<0.001) decrease blood glucose level compared to diabetic control (DC) group. The serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT) and C- reactive protein (CRP) were also decreased significantly (p<0.001). An indicative antilipidemic effect was also observed as total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL) showed significant (p<0.05) decrease whereas HDL showed significant increase (p<0.001) by the treatment compared to DC group. From the above observations it can be concluded that the honey, C. cordifolia leaves extract and HFO have an effective therapeutic value in the treatment of DM and in the management of associated cardiovascular and hepatic complications.