Journal of Nanomedicine & Nanotechnology

Abstract

Comparative Anti-Bacterial Activity of Differently Capped Silver Nanomaterial on the Carbapenem Sensitive and Resistant Strains of Acinetobacter baumannii

Monalisa Tiwari, Rama Raghav and Vishvanath Tiwari

Acinetobacter baumannii is an opportunistic Gram-negative pathogen causes pneumonia, respiratory infections and urinary tract infections and emerged as a serious pathogen for the immuno-compromised patients. Its prevalence increases gradually in the clinical setup. Carbapenem are most effective antibiotics against A. baumannii. Emergence of resistance of A. baumannii against carbapenem will leads to the high mortality and morbidity. Therefore, there is a high time to develop antibiotic alternative drug against carbapenem resistant strain of A. baumannii. In present work, we have synthesized and characterized silver nanoparticle (AgNPs) capped with different agents like polyvinylpyrrolidone (PVP), sodium citrate, chitosan, sodium dodecyl sulfate (SDS). Antibacterial effect of these capped AgNPs has been checked on the carbapenem resistant and sensitive strains of A. baumannii using UV-Vis Spectrometer. It was found that PVP and sodium citrate capped AgNPs are more effective while chitosan and SDS capped AgNPs shows little effect (only at high concentration) on the carbapenem resistant strain of A. baumannii. The result also highlighted the synergism between differentially capped AgNPs with carbapenem. Interestingly, we have found that the synergism between AgNPs and antibiotics is also dependent on the resistant level of pathogen. Result also shows that the total protein content of the both the strains is decrease in the presence of capped AgNPs. Result concludes that PVP capped AgNPs might be suitable replacement of carbapenem or can be used along with carbapenem to cure the infection caused by carbapenem resistant strain of A. baumannii.