Journal of Clinical & Experimental Pharmacology

Abstract

Combination of Coq10, Omega 3 and Zinc Improves the Severity of Experimental Arthritis by Inhibiting the Immune-inflammatory Response

Seon-Yeong Lee,Seung Hoon Lee,Jin Hee Yoo,Se-Young Kim,Jooyeon Jhun,HyeonBeom Seo,KyungAh Jung,Chul-Woo Yang,Sung-Hwan Park*,Mi-La Cho*

Omega 3, zinc and coenzyme Q10 (CoQ10) are used as dietary supplements revealing an anti-inflammatory function. Individually they have been recognized as important players in rheumatoid arthritis (RA). However, there is no evidence of the synergic effect of omega 3, zinc and CoQ10 in RA. This study aims to identify if omega 3, zinc and CoQ10 can improve the progression of zymosan-induced arthritis (ZIA) using a mouse model. Results showed that the combination of omega 3, zinc and CoQ10 decreased ZIA severity decreasing IgG levels, joint inflammation and cartilage damage. The combination of omega 3, zinc and CoQ10 reduced interleukin (IL)-6, -17, tumor necrosis factor (TNF)-? and interferon (IFN)-? expression. There was also a decrease in osteoclastogenesis with the combination of omega 3, zinc and CoQ10. These observations demonstrate that the combination of omega 3, zinc and CoQ10 improved ZIA progression by reducing proinflammatory cytokines expression compared to CoQ10 alone. Thus, the combination of omega 3, zinc and CoQ10 presents as an important preventive measure in RA, which can aid in understanding in it pathogenesis.