Biology and Medicine

Abstract

Chemoprotective activity of hydro-ethanolic extract of Euphorbia neriifolia Linn leaves against DENA-induced liver carcinogenesis in mice

Pracheta, *Sharma V, Paliwal R, Sharma S, Singh L, Janmeda BS, Savita, Yadav S, Sharma SH

Liver cancer is one of the leading causes of cancer death worldwide. This idea has prompted to evaluate the hepatoprotective properties of hydro-ethanolic extract of Euphorbia neriifolia (EN) Linn against N-Nitrosodiethylamine (DENA) induced liver cancer in mice. Male mice were pre-administered with EN extract (150 and 400 mg/kg body weight; p.o.) and standard (0.5% BHA) prior to single dose of DENA (50 mg/kg body weight; p.o.). Various in vivo biochemical parameters like lipid peroxidation, superoxide dismutase and catalase were evaluated to determine the hepatoprotective and antioxidant activity of EN. DENA significantly increased LPO and decreased the endogenous antioxidant enzymes (SOD and CAT). The EN extract significantly restored the antioxidant enzyme level in the liver and exhibited significant dose dependant protective effect against DENA induced liver toxicity, which can be mainly attributed to the antioxidant property of the extract. This study rationalized the ethno-medicinal use of the EN for curing liver cancer