Journal of Neonatal Biology

Abstract

Can the Score for Neonatal Acute Physiology II (SNAPII) Predict Morbidity and Mortality in Neonates with Sepsis?

Nahed Fahmy Helal, Nashwa Mamdouh Samra, Eman Abdel Ghany Abdel Ghany and Ebtehal Adel Said

Objective: We investigated whether Score for Neonatal Acute Physiology II (SNAP II) score can predict mortality and or Organ Dysfunction (OD) in neonatal sepsis. Methods: Eighty Egyptian newborns hospitalized for neonatal sepsis were investigated through a multicenter observational prospective study to determine whether SNAP II applied in the 1st 12 hours of admission would predict mortality and or OD. Results: The median SNAP II was significantly higher in babies who died or developed OD versus those who survived and improved (P=0.003 and P=0.001 respectively). Individual parameters of the SNAP II didn’t contribute equally to the risk of death, low mean arterial blood pressure and lowest blood pH were significantly associated with OD and death (P=0.002). ROC curves for the SNAP II score ≥ 40 showed moderate predictive accuracy and 90.4% and 88.9% sensitivity for OD and death, respectively. Conclusion: SNAP II score can predict mortality and OD in neonatal sepsis.