Biochemistry & Analytical Biochemistry

Abstract

Bilirubin as a New Biomarker of Diabetes and its Microvascular Complications

Takeshi Nishimura, Masami Tanaka, Risa Sekioka and Hiroshi Itoh

Hyperglycemia is the hallmark of diabetes mellitus [DM]; it activates certain biochemical pathways leading to micro- and macrovascular complications in diabetic patients. Moreover, hyperglycemia generates oxidative stress and causes free radicalmediated lipid peroxidation. In turn, the oxidative stress causes endothelial dysfunction, and has been suggested as one of the important mechanisms underlying the onset and progression of diabetic vascular complications.