Dentistry

Abstract

Assessment of Efficacy of PAP, Acridine Orange and AGNOR in Detecting Micronuclei in Oral Exfoliative Smears in Smokers-A Cross Sectional Comparative Study

D Anupriya*, Harini Priya A. H, R Sathish Muthukumar and Sreeja C

Cigarette smoking is the major cause of oral cancer, which accounts for around two-thirds of all reported cases of oral squamous cell carcinomas annually. Tobacco use in any form is considered as a behavioural process which elicits physiological and psychologic addictive mood among users. Smoking leads to various adverse health effects. A cigarette contains over 4000 identifiable chemical carcinogens, with 200 known carcinogens that show toxicity. Comparing other anatomic sites of our body, the oral cavity shows high tendency for developing malignancy. This is because, oral cavity acts as the first barrier in the route of inhalation or ingestion of food and it can metabolize procarcinogens contained in tobacco smoke to reactive products. This may be due to the nature of the oral mucosa which is made of stratified non keratinized epithelia, which allows the superficial cells to maintain an intact structure and in turn promoting colour absorption and easy observation of nuclear characteristics under the microscope.

Published Date: 2024-08-29; Received Date: 2020-07-06