Journal of Clinical and Medical Sciences

Abstract

Assessment of Crises Severity in Sickle-Cell Anemia Patients using Hydroxyurea Drug-West of Sudan

Tariq. E. Elmissbah

ABSTRACT

Objective: This study was designed to assess crises in Sickle-anemia patients who using hydroxurea as treatment in West of Sudan via an estimation of blood parameters and Hemoglobin F (HbF) levels. Methods: A descriptive, cross-sectional study was done in Heglih hospital, West Sudan. A total of 115 SCA patients were included in this study; 73 of them used hydroxurea and don't use. We compared results of both group with 50 healthy individual. Results: The results showed that the level of Hb F in SCA patients residing inside the petroleum area was significantly higher than patients who live outside the petroleum area (p<0.001), it was also elevated in controls residing outside the petroleum area. Also this study proved that 25% of patients had no symptoms, but the rest of the patients had symptoms ranging between haemolytic crises (43%), vasoocclusion crises (26%), and both hemoylytic and vasooclussive crises (7%). Conclusion: Hydroxyurea therapy should, in our opinion, be regarded standard-of-care for SCA and an important part of patient management. Early hydroxyurea treatment and widespread use will change the natural course of SCA, allowing affected children to enjoy longer and better lives.

Published Date: 2023-12-27; Received Date: 2023-11-26