Biology and Medicine

Abstract

Aqueous extracts of Sphagneticola trilobata attenuates streptozotocin-induced hyperglycaemia in rat models by modulating oxidative stress parameters

IJ Kade, NBV Barbosa, EO Ibukun, AP Igbakin, CW Nogueira, JBT Rocha

Male albino rats with diabetes induced by the administration of streptozotocin (45 mg/kg, i.v.) were treated with oral administration of Sphagneticola trilobata (S. tri). S.tri reduced blood glucose levels and improved weight gained which was accompanied by a marked restoration of decreased vitamin C and reduced glutathione in liver and kidney tissues) of STZ-treated rats. In vitro data revealed that S.tri caused an inhibition of lipid peroxidation under Fe2+ or sodium nitroprusside assaults. Conversely, S. tri also caused a reduction in the high levels of thiobarbituric acid reactive substances (TBARS) observed in the liver, kidney, and testes as well as high serum triglyceride, ALT and AST of diabetic rats. Finally, the inhibition of catalase, delta aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase accompanied by hyperglycemia were relieved by S. tri in all tissues examined. Hence, the empirical use of S. tri in folkloric medicine may have some scientific justification.