Pharmaceutica Analytica Acta

Abstract

Application of Fourier Function to Double Divisor Ratio Spectra Curves for Analysis of Some Amoebicide Drugs in Their Ternary Mixtures

Nada S Abdelwahab and Eglal A Abdelaleem

This work concerns with development of spectrophotometric methods for analysis of Metronidazole, Diloxanide Furoate and Mebeverine HCl. Method (I) is double divisor ratio spectra derivative method (DDRD) which depends on using derivative signals of the ratio spectra using double divisor. Method (II) is hybrid double divisor ratio spectra (HDDR) which depends on convolution of the double divisor ratio spectra using trigonometric Fourier functions. The developed HDDR method showed better selectivity than DDRD due to its higher resolution power. The methods have been applied for analysis of the studied drugs in their commercial tablets and the results obtained from the analysis of the market sample by the proposed methods were statistically compared with those obtained by manufacturer RP-HPLC method.