Clinical Microbiology: Open Access

Abstract

Anti-inflammatory effect of Linum usitassimum (Flaxseed/linseed) fixed oil on inflammatory bowel disease in mice.

Yanat Betitra

Currently, there are several therapeutic options for inflammatory bowel disease (IBD). However, they may have possible adverse effects or even relatively significant efficacy. The fixed oil of flaxseed (Linum usitassimum) is known for its high content of omega 3 fatty acids and proteins acting as stimulators of the immune system. Thus, the main objective of this study was to study the anti-inflammatory activity of the fixed oil of flaxseed on a mouse model and its effect on the gut microbiota. The anti-inflammatory effect of the fixed oil was tested with doses of 50 and 100 mg/kg on acetic acid-induced colitis on an animal model (albino mice) for 48 hours. In parallel, a bacteriological analysis of the faecal flora of each lot (healthy, sick and treated by fixed oil) was carried out by the enumeration of Escherichia coli on selective medium.

Published Date: 2021-02-12;