Biology and Medicine

Abstract

Analysis of Dental Implants Biointegration in Animals

Alexander V. Krasnikov, Vyacheslav V. Annikov, Yury A. Vatnikov, Elena D. Sotnikova, Evgeny V. Kulikov and Valentina I. Parshina

This article presents characterization study of new coatings for dental implants, defines their basic requirements, and discusses the prospects of thermal oxide coatings application in animals’ dental implantology. Thermally oxidized implants, modified with nanoaggregates of flavonoids, possess a greater degree of osteointegration as compared with the implants without coating. It was revealed in vitro that during the research control period, fibroblasts were adherenced around the implants’ blanks on samples with a nontoxic coating of polyazolidine ammonium modified by the hydrate flavonoids’ halogen ions. It is revealed that the experimental implants do not exert inhibitory action on erythropoiesis and leukopoiesis. The lack of sharp fluctuations in the levels of calcium and phosphorus, the dynamics of bilirubin, creatinine and urea within the reference values, as well as the recovery of the initial level of aspartate transaminase, alanine aminotransferase and C-reactive protein in animals of the experimental group at the early stages indicate the absence of toxic influence of implants with thermally oxidized surface coated through induction heat treatment and modified by nanoaggregates of flavonoids.