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Abstract
Advances in Bioinformatics Tools for High-Throughput Sequencing Data of DNA Methylation
Jianzhong Su, Dan Huang, Haidan Yan, Hongbo Liu and Yan Zhang
DNA methylation plays crucial roles in regulating gene expression during cellular development and differentiation. Recently, Next-generation sequencing (NGS) technologies spurred a revolution in investigating global DNA methylation profiles. Analysis of DNA methylation patterns on a genome-wide scale is essential to understanding the underlying mechanisms of DNA methylation. Here, we reviewed several next-generation sequencing techniques coupled with different pretreatment methods (endonuclease digestion, affinity enrichment and bisulfite conversion) and summarized the relative bioinformatics tools and resources for further analysis of DNA methylation.