Awards Nomination
20+ Million Readerbase
Indexed In
- Open J Gate
- Genamics JournalSeek
- ResearchBible
- RefSeek
- Directory of Research Journal Indexing (DRJI)
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- Scholarsteer
- Publons
- MIAR
- Euro Pub
- Google Scholar
Useful Links
Share This Page
Journal Flyer
Open Access Journals
- Agri and Aquaculture
- Biochemistry
- Bioinformatics & Systems Biology
- Business & Management
- Chemistry
- Clinical Sciences
- Engineering
- Food & Nutrition
- General Science
- Genetics & Molecular Biology
- Immunology & Microbiology
- Medical Sciences
- Neuroscience & Psychology
- Nursing & Health Care
- Pharmaceutical Sciences
Abstract
Activation of Microbial Silent Gene Clusters: Genomics Driven Drug Discovery Approaches
Jinu Mathew Valayil
Microorganisms have provided mankind with a plethora of small molecule natural products ranging from industrial enzymes to therapeutic agents. Analyses of microbial genome sequences have revealed the presence of numerous ‘silent’ or ‘cryptic’ biosynthetic gene clusters (BGCs). Activation of these cryptic biosynthetic pathways can pave way to the discovery of novel bioactive secondary metabolites (SMs). This article summarizes various approaches employed to unlock the hidden biosynthetic potential of microbes and methods developed to study their silent gene products.