Pharmaceutica Analytica Acta

Abstract

A New Preparation Method for Ophthalmic Drug Nanoparticles

Noriaki Nagai and Yoshimasa Ito

The most challenging task in ophthalmic therapy has long been the formulation of suitable ocular drug delivery systems due to the unique structure of the eye that restricts entry of the drug molecule at the site of action. Recently, the use of nanotechnology in the ophthalmic field has gained much attention, since nanoparticulate drug delivery is considered to be one of the most promising technologies to overcome poor drug stability and the difficulties in delivering drugs across biological barriers (improvement of bioavailability). This review demonstrates the usefulness of ophthalmic formulations containing drug nanoparticles. Furthermore, in this review, we introduce a new method established in our laboratory for the preparation of drug solid nanoparticles. This information provides significant information that can be used to design further studies aimed at developing less toxic eye drops.